Cardiometabolic SIG

SIG name

Cardiometabolic

SIG leaders

  • Trevor Mori, School of Medicine and Pharmacology, University of Western Australia (trevor.mori@uwa.edu.au)
  • Koya Ayonrinde, School of Medicine and Pharmacology, UWA; Department of Gastroenterology and Hepatology, Fiona Stanley Hospital; Faculty of Health Sciences, Curtin University (ayonrinde@uwa.edu.au)

List of local investigators (name and affiliation)

  • Trevor Mori, School of Medicine and Pharmacology, UWA
  • Lawrie Beilin, School of Medicine and Pharmacology, UWA
  • Chi Le-Ha, School of Medicine and Pharmacology, UWA
  • Sally Burrows, School of Medicine and Pharmacology, UWA
  • Sunil Bhat, School of Medicine and Pharmacology, UWA
  • Anahita Hamidi, School of Medicine and Pharmacology, UWA
  • Denise Demmer, School of Medicine and Pharmacology, UWA
  • Koya Ayonrinde, School of Medicine and Pharmacology, UWA; Department of Gastroenterology and Hepatology, Fiona Stanley Hospital; Faculty of Health Sciences, Curtin University
  • John Olynyk, Department of Gastroenterology and Hepatology, Fiona Stanley Hospital; School of Medical and Health Sciences, Edith Cowan University; Faculty of Health Sciences, Curtin University
  • Leon Adams, School of Medicine and Pharmacology, UWA; Department of Hepatology, Sir Charles Gairdner Hospital
  • Luis Calzadilla Bertot, School of Medicine and Pharmacology, UWA; Department of Hepatology, Sir Charles Gairdner Hospital
  • Rae-Chi Huang, Telethon Kids Institute, UWA
  • Phillip Melton, Centre for Genetic Origins of Health and Disease, UWA
  • Gina Ambrosini, School of Population and Global Health, UWA
  • Therese O’Sullivan, School of Medical and Health Sciences, ECU
  • Wendy Oddy, Menzies Institute for Medical Research, University of Tasmania

Overview of the current data resources available in the SIG area

  • Generation 2 bloods at 14, 17, 20, 22, 27 yr follow-ups
  • Generation 1 bloods at 14, 17, 22 yr follow-ups
  • Generation 3 bloods
  • Liver ultrasound, visceral and subcutaneous fat thickness at 17yr of Generation 2

Overview of current/recent SIG activity

Cardiometabolic Group

Focus on examining BP, anthropometry, pregnancy, familial, socio-behavioural & biochemical variables in relation to cardiovascular risk

  • Genetic and early life predictors of ectopic fat & their association with cardiometabolic health and disease
  • Age at menarche and umbilical cord blood in relation to CV risk (Hickey, Melb)
  • Gen-2 Parents sleep study (Eastwood)
  •  Gen-3 autism study (Whitehouse)
Liver Group
  • Focus on NAFLD in adolescents and adults; tracking intergenerational and developmental risk factors, nutritional, physical activity, genetic, metabolic and microbiome associations with NAFLD.

Outline of SIG plans for next 5 years

Cardiometabolic Group
  • Genetic and Early Life Predictors of Ectopic Fat and their Association with Cardiometabolic Health and Disease (continuation of NHMRC Project Grant)
  • Developmental Origins of Adult Cardiovascular Disease: Vascular Health in the Raine Cohort (new NHMRC Project Grant)
  • Gen-3 autism study – (Whitehouse et al.)
  • Expansion and validation of measures of distant early-life diet patterns – proposed NIH submission (Mori, Ambrosini, Straker, Oddy, Beilin) in collaboration with S Sutcliffe (Washington University School of Medicine, St. Louis, USA)
Liver Group
  • Submitted NHMRC Project Grant (Olynyk, Adams, et al.). Impaired iron bioavailability and haemoglobin production in young adults with NAFLD: determining the mechanism and impact on physical capacity and activity.
  • Intergenerational heritability of NAFLD, longitudinal tracking of the NAFLD   phenotype and extra-hepatic disease associations adolescents and young adults (Ayonrinde, Olynyk, Adams)
  • Gut microbiome and NAFLD (collaboration)
  • The Epidemiology, Origins and Associations of Irritable Bowel Syndrome in Western Australian Adolescents (Ayonrinde, Adams, Olynyk, O’Sullivan, Robinson, Oddy, Ayonrinde)

Brief list of potential student/early career researcher projects

Please contact the Cardiometabolic SIG Leaders if you are interested in a research project incorporating cardiometabolic data and they will coordinate whom to contact within the group.

List of National/International Collaborating Investigators (name and affiliation)

  • Martha Hickey, The Royal Women’s Hospital, University of Melbourne
  • Berthold Koletzko, University of Munich, Germany
  • Vincent Jaddoe, GenR Study, Rotterdam, The Netherlands
  • Paul Leeson, Oxford University, UK, GIANT & CHARGE consortia
  • Siobhan Sutcliffe, Washington University School of Medicine, St. Louis, USA
  • University Putra Malaysia
  • Oxford University
  • Charles Perkins, University of Sydney

Top 5-10 key findings (with reference)

  • Maternal exposure to life stresses during pregnancy predicts increased weight but lower blood pressure in offspring at 20 years of age. (Bhat SK, Beilin LJ, Robinson M, Burrows S, Mori TA. Contrasting effects of prenatal life stress on blood pressure and body mass index in young adults. J Hypertens 2015;33:711–19.
  • Passive smoking exposure over childhood and adolescence predicts reduced HDL-cholesterol during adolescence in girls but not boys. (Le-Ha C, Beilin LJ, Burrows S et al. Gender difference in the relationship between passive smoking exposure and HDL-cholesterol levels in late adolescence. J Clin Endocrinol Metab 2013;98:2126–35.
  • An adiposity trajectory characterized by an accelerated rate of growth in infancy predicts greater insulin resistance in adolescence. (Huang RC, de Klerk NH, Smith A et al. Diabetes Care 2011;34:1019–25)
  • Epigenetic studies have identified DNA methylation related to adiposity in young adulthood. (Huang RC, Galati JC, Burrows S et al. Clin Epigenet 2012;4:21)
  • Gender differences between parental pregnancy characteristics and nonalcoholic fatty liver disease in adolescents. (Ayonrinde OT, Adams LA, Mori TA, Beilin LJ, de Klerk N, Pennell CE, White S, Olynyk JK. Hepatology 2017, in press)
  • Adverse metabolic phenotype of adolescent girls with non-alcoholic fatty liver disease plus polycystic ovary syndrome compared with other girls and boys. (Ayonrinde OT, Adams LA, Doherty D, Mori TA, Beilin LJ, Oddy WH, Hickey M, Sloboda D, Olynyk JK, Hart R. J Gastroenterology Hepatology 2016; 31: 980-987).
  • Positive association between handgrip strength and back muscle endurance with systolic blood pressure throughout childhood and adolescence contrasts with beneficial effects on other related traditional cardiometabolic risk factors. (Demmer DL, Beilin LJ, Hands B, Burrows S, Cox K, Straker L, Mori TA. J Hypertension 2016, 34: 2365-2375).

List of indicative recent publications

  • Ayonrinde OT, Olynyk JK, Marsh JA, Beilin LJ, Mori TA, Oddy WH, Adams LA. Childhood Adiposity Trajectories and Risk of Nonalcoholic Fatty Liver Disease in Adolescents. J Gastroenterology Hepatology, 2015, 30: 163-171.
  • Davis EF, Lewandowski AJ, Aye C, Williamson W, Boardman H, Huang RC, Mori TA, Newnham J, Beilin LJ, Leeson P. Clinical cardiovascular risk during young adulthood in offspring of hypertensive pregnancies: insights from a 20 year prospective follow-up birth cohort. BMJ Open 2015; 5: e008136 doi: 10.1136/bmjopen-2015-008136 (pages 1-8).
  • Huang R-C, Burrows S, Mori TA, Oddy WH, Beilin LJ. Lifecourse adiposity and blood pressure between birth and 17 years old. Am J Hypertension 2015, 28(8): 1056-1063.
  • Le-Ha C, Herbison CE, Beilin LJ, Burrows S, Henley DE, Lye SJ, Matthews SG, Pennell CE, Mori TA. High Hypothalamic-pituitary-adrenal axis activity under resting conditions and cardiovascular risk factors in adolescent. Psychoneuroendocrinology 2016, 66: 118-124.
  • Gaillard R, Welten M, Oddy WH, Beilin LJ, Mori TA, Jaddoe VWV, Huang R-C. Associations of maternal pre-pregnancy body mass index and gestational weight gain with cardio-metabolic risk factors in adolescents. Br J Obstetrics Gynaecol 2016; 123(2): 207–216.
  • Pang J, Martin AC, Mori TA, Beilin LJ, Watts GF. Frequency of familial hypercholesterolaemia in adolescents: potential value of universal screening? Journal of Pediatrics 2016; 170: 315-316. Familial Hypercholesterolemia: Editorial: The Reason to Screen Children for Cholesterol Abnormalities. Daniels SR. J Pediatrics 2016; 170: 7-8.
  • Rauschert S, Uhl O, Koletzko B, Kirchberg F, Mori TA, Huang R-C, Beilin LJ, Hellmuth C, Oddy WH. Lipidomics reveals associations of phospholipids with obesity and insulin resistance in young adults. J Clin Endocrinol Metab 2016, 101(3): 871-879.
  • Rauschert S, Uhl O, Koletzko B, Mori TA, Beilin LJ, Oddy WH, Hellmuth C. Sex Differences in the Association of Phospholipids with Components of the Metabolic Syndrome in Young Adults. Biology of Sex Differences, 2017, in press.
  • Ayonrinde OT, Oddy WH, Adams LA, Mori TA, Beilin LJ, de Klerk N, Olynyk JK. Infant nutrition and maternal obesity prospectively influence the risk of nonalcoholic fatty liver disease in adolescents. J Hepatology 2017, in press.
  • Rauschert S, Mori TA, Beilin LJ, Jacoby P, Uhl O, Koletzko B, Oddy WH, Hellmuth C. Early life factors, obesity risk and the metabolome of young adults. Obesity 2017, in press.

List of current/recent grants

  • NHMRC (1059711) – The Cycle Of Obesity: A two generation population study of obesity epigenetics.  R-C Huang, K Lillycrop, J Craig, L Beilin, T Mori, W Oddy, K Godfrey, J Holbrook, G Burdge.  2014-2018
  • NHMRC (1102106) – Genetic and Early Life Predictors of Ectopic Fat and their Association with Cardiometabolic Health and Disease.  TA Mori, LJ Beilin, E Moses, G Watts, L Adams.  2016-2010
  • NHMRC (APP1126494) – Developmental Origins of Adult Cardiovascular Disease: Vascular Health in the Raine Cohort.  D Green, L Beilin, L Straker, P Eastwood, T Mori, P Ainslie.  2017-2020

Examples of recent media