Risk factors for the development of cardiovascular disease include tobacco smoking, poor nutrition, physical inactivity, being overweight or obese, high blood pressure or cholesterol, diabetes or high alcohol consumption. Information from the Raine Study is utilised to better characterise the problem of childhood obesity, and enhance our understanding of childhood nutrition and lifelong cardio-metabolic health outcomes.
The cardio-metabolic group has been examining and published on the effects of prenatal and postnatal factors, lifestyle and environmental factors on cardio-metabolic health during childhood, adolescence and adulthood. Risk factors for poor cardio-metabolic health include: high blood pressure; impaired vascular function; and increased blood lipids, insulin resistance and inflammatory markers. The group is examining childhood trajectories for adiposity, blood pressure and insulin resistance, and the association between parental and adolescent adiposity and cardio-metabolic risk. Another aspect of the research is examining the effect of antenatal and postnatal life stress on cardio-metabolic risk factors in young adulthood. Overall we anticipate that our research will enable a better understanding of how pregnancy, childhood and adolescent exposures interact with social and environmental factors to affect the long-term risk of adult obesity, diabetes and cardiovascular disease.
Cardiovascular team members
Emeritus Professor Lawrie Beilin AO MBBS, MD, FRCP, FRACP
Research Professor Trevor Mori PhD
A/Professor Rae-Chi Huang MBBS PhD
A/Professor Sally Burrows BMATH
Dr Wendy Chen She Ping-Delfos PhD
Professor Wendy Oddy MPH PhD
Ms Lyn McCahon
Dr I-Jung Tsai PhD
Dr Lucinda Black PhD
Dr Paul Leeson
Dr Esther Davis
Mr Adam Lewandowski
Cardiovascular Clinical Research Facility, University of Oxford
Professor Berthold Koletzko
University of Munich, Germany
Dr Chi Le-Ha MBBS, PhD Candidate
Denise Demmer PhD Candidate
Dr Sunil Bhat MBBS MPH, PhD Candidate
Dr Anahita Hamidi, PhD Candidate
- 2014 WA Telethon, Perth Children's Hospital Research Fund, RC Huang, E Davis, L Beilin, C Pennell, TPCHRF - Bedside to bench and back to paediatric obesity clinic: Enabling a powerful West Australian epigenetic resource, $200,000.
- 2014-2016 NHMRC 1059655 RC Huang, K Lillycrop, G Burdge, J Craig, L Beilin, T Mori, W Oddy, K Godfrey, J Holbrook, Breaking the intergenerational cycle of obesity: a multigeneration population study of obesity epigenetics, $1,086,101.
- 2013 UWA Research Collaboration Award, RC Huang, G Burdge, V Jaddoe,W Oddy, E Davis, Early life programming of childhood obesity, $15,000.
- 2012, Ada Bartholomew Trust, W Chan She Ping Delfos, Long term deprivation of Vitamin D on risk of metabolic syndrome in the Raine Cohort, $30,000.
- 2012-2013, Dairy Health and Nutrition Consortium (DHNC), T O'Sullivan, W Oddy, T Mori, Redefining 'good' fats: Are regular fat dairy products associated with lower metabolic syndrome risk than low fat products in adolescence? $102,654.
- 2012-2014, NHMRC 1037966, W Oddy, T Mori, L Adams, S Byrne, Nutritional determinants of cardiometabolic risk and mental health: from infancy to adulthood, $481,725.
- 2012-2014, NHMRC 1030148, W Oddy, F Stanley, L Beilin, C Pennell, B Koletzko, Demmelmair, WG Peissner, Analysis of metabolic profiles in young adults from the the Western Australian Pregnancy Cohort (Raine) Study by metabolomics: biomarkers for metabolic consequences of early programming by infant feeding type, $323,250.
- 2010-2012, NHMRC 634445, L Adams, J Olynyk, L Beilin, C Pennell, W Oddy, P McCaskie, Risk factors for the development of NAFLD beyond insulin resistance: genetic, developmental and environmental influences, $641,125.
- 2010-2015 CIH, S Lye, C Pennell, L Adams, L Beilin, L Briollais, S Matthews, J Newnham, J Olynyk, L Palmer. Gene-Environment interactions underlying the development origins of health and disease. $876,529.
- 2010-2015, NHMRC 1022134, W Oddy, T Mori, L Adams, S Byrne. Nutritional determinants of cardio-metabolic risk and mental health disorders: from infancy to adulthood, $481,725.
- 2009-2011, National Heart Foundation, W Oddy, GL Ambrosini, SR Silburn, LJ Beilin, TA Mori.. A prospective study of major dietary patterns and mental health of adolescents, $434,375.
- 2009-2011, NHMRC 572613, L Palmer, C Pennell, L Beilin, J Newnham, S Lye, G Davey-Smith, Genome wide association study, $989,500.