Asthma and Allergy

Asthma and Allergy


Asthma is a chronic inflammatory condition of the airways associated with episodes of wheezing, breathlessness and feeling of chest tightness. There is currently no cure for asthma and it remains a significant health problem in Australia. It is estimated that approximately 2 million Australians, or 1 in 10, are asthmatic (Australian Centre for Asthma Monitoring, 2011) and in 2012 unfortunately 394 people died as a result of asthma.  People of all ages can be affected by asthma; it can occur for the first time at any age, but starts most often in childhood.


Extensive research into the development of asthma and allergy has been conducted within the Raine Study and collaborating research groups. Ongoing projects include investigations into the molecular basis of asthma, the epidemiology through to genome wide association studies to unravel the genetic and environmental factors contributing to asthma and allergy. The Raine Study cohort participants have undergone extensive allergy and lung function testing at 5, 14 and now at 23 years of age.


Research Team

Professor Patrick Holt PhD FRCPath

Professor Graham Hall PhD FANZSRS

Professor Peter Sly PhD MD FRACP

Dr Elysia Hollams PhD

Professor Jenefer Blackwell PhD, DSc, ScD

Dr Shelley Gorman PhD

Dr Merci Kusel MBBS PhD

Professor Alan James MBBS, FRACP, MD

Professor Nick de Klerk MSc PhD

Dr Anthony Bosco PhD



Elisha White, PhD Candidate

Rachel Foong, PhD Candidate



2012-2014, NHMRC 1021858, G Hall, P Holt, E Hollams, Z Hantos. Transition from childhood to adult asthma: Predicting persistent and adult‐onset asthma in young adults in the Raine longitudinal birth cohort, $984,248.


2012, Asthma Foundation WA, A Bosco, G Hall, Elucidation of atopic asthma endotypes via differential co-expression analysis of airway inflammatory gene networks, $18,300.



Asthma Team